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RNA-SEQ DATA-MINING ALLOWS THE DISCOVERY OF TWO LONG NON-CODING RNA BIOMARKERS OF VIRAL INFECTION IN HUMANS
Ruth Barral-Arca, Alberto Gómez-Carballa, Miriam Cebey-López, María José Currás-Tuala, Sara Pischedda, Sandra Viz-Lasheras, Xabier Bello, Federico Martinón-Torres and Antonio Salas
Journal:
International J Molecular Sciences
Publicación independiente
Impact factor
5.924
Q1
Year:
2020
Doi:
https://doi.org/10.3390/ijms21082748
COST OF RESPIRATORY SYNCYTIAL VIRUS-ASSOCIATED ACUTE LOWER RESPIRATORY INFECTION MANAGEMENT IN YOUNG CHILDREN AT THE REGIONAL AND GLOBAL LEVEL: A SYSTEMATIC REVIEW AND META-ANALYSIS.
Zhang S, Akmar LZ, Bailey F, Rath BA, Alchikh M, Schweiger B, Lucero MG, Nillos LT, Kyaw MH, Kieffer A, Tong S, Campbell H, Beutels P, Nair H; RESCEU Investigators
Journal:
J Infect Dis.
Publicación independiente
Impact factor
5.226
Q1
Year:
2020
Doi:
IMMUNOLOGICAL AND INFLAMMATORY BIOMARKERS OF SUSCEPTIBILITY AND SEVERITY IN ADULT RESPIRATORY SYNCYTIAL VIRUS INFECTIONS.
Wiseman DJ, Thwaites RS, Drysdale SB, Janet S, Donaldson GC, Wedzicha JA, Openshaw PJ; RESCEU Investigators
Journal:
J Infect Dis.
Publicación independiente
Impact factor
5.226
Q1
Year:
2020
Doi:
LOW SENSITIVITY OF BINAXNOW RSV IN INFANTS.
Zuurbier RP, Bont LJ, Langedijk AC, Hamer M, Korsten K, Drysdale SB, Snape MD, Robinson H, Pollard AJ, Martinón-Torres F, Rodríguez-Tenreiro Sánchez C, Gómez-Carballa A, Dacosta-Urbieta AI, Heikkinen T, Cunningham S, van Houten MA, Wildenbeest JG; RESCEU Investigators .
Journal:
J Infect Dis.
Publicación independiente
Impact factor
5.226
Q1
Year:
2020
Doi:
https://doi.org/10.1093/infdis/jiaa050
PROTECTING THE MOST VULNERABLE AGE GROUP: A REVIEW OF MENACWY-TT IMMUNOGENICITY AND SAFETY IN INFANTS.
Martinón-Torres F, Serra L, Safadi MAP.
Journal:
Expert Rev Vaccines
Publicación independiente
Impact factor
5.217
Q2
Year:
2020
Doi:
https://doi.org/10.1080/14760584.2020.1745070
PATHWAY TOWARDS AN IDEAL AND SUSTAINABLE FRAMEWORK AGREEMENT FOR THE PUBLIC PROCUREMENT OF VACCINES IN SPAIN: A MULTI-CRITERIA DECISION ANALYSIS.
Zozaya González N, Alcalá Revilla B, Arrazola Martínez P, Chávarri Bravo JR, Cuesta Esteve I, García Rojas A, Martinón-Torres F, Redondo Margüello E, Rivero Cuadrado A, Tamames Gómez S, Villaseca Carmena J, Hidalgo-Vega A
Journal:
Hum Vaccine Immunother
Publicación independiente
Impact factor
3.452
Q2
Year:
2020
Doi:
https://doi.org/10.1080/21645515.2020.1732164
WHOLE-EXOME SEQUENCING FOR THE IDENTIFICATION OF RARE VARIANTS IN PRIMARY IMMUNODEFICIENCY GENES IN CHILDREN WITH SEPSIS - A PROSPECTIVE POPULATION-BASED COHORT STUDY
Alessandro Borghesi, Johannes Trück, Samira Asgari, Vanessa Sancho-Shimizu, Philipp KA Agyeman, Evangelos Bellos, Eric Giannoni, Martin Stocker, Klara M Posfay-Barbe, Ulrich Heininger, Sara Bernhard-Stirnemann, Anita Niederer-Loher, Christian R Kahlert, Giancardlo Natalucci, Christa Relly, Thomas Riedel, Claudia E Kuehni, Christian W. Thorball, Nimisha Chaturvedi, Federico Martinon-Torres, Taco W Kuijpers, Lachlan Coin, Victoria Wright, Jethro Herberg, Michael Levin, Christoph Aebi, Christoph Berger, Jacques Fellay, Luregn J Schlapbach, for the EUCLIDS consortium and the Swiss Paediatric Sepsis Study
Journal:
Clin Infect Dis
Publicación independiente
Impact factor
9.079
Q1
Year:
2020
Doi:
https://doi.org/10.1093/cid/ciaa290
A META-ANALYSIS OF MULTIPLE WHOLE BLOOD GENE EXPRESSION DATA UNVEILS A DIAGNOSTIC HOST-RESPONSE TRANSCRIPT SIGNATURE FOR RESPIRATORY SYNCYTIAL VIRUS
Ruth Barral-Arca, Alberto Gómez-Carballa, Miriam Cebey-López, Xabier Bello, Federico Martinón-Torres, and Antonio Salas
Journal:
Int. J. Mol. Sci.
Publicación independiente
Impact factor
5.924
Q1
Year:
2020
Doi:
https://doi.org/10.3390/ijms21051831
RESPIRATORY SYNCYTIAL VIRUS-ASSOCIATED ACUTE LOWER RESPIRATORY INFECTIONS IN CHILDREN WITH BRONCHOPULMONARY DYSPLASIA: SYSTEMATIC REVIEW AND META-ANALYSIS.
Chaw PS, Hua L, Cunningham S, Campbell H, Mikolajczyk R, Nair H; RESCEU Investigators (Nair H, Campbell H, Shi T, Zhang S, Li Y, Hua L, Openshaw P, Wedzicha J, Falsey A, Miller M, Bont L, Pollard A, Molero E, Martinon-Torres F, Heikkinen T, Meijer A, Fischer TK, van den Berge M, Giaquinto C, Mikolajczyk R, Chaw PS, Gallichan S, Kieffer A, Demont C, Hackett J, Cai B, Knirsch C, Leach A, Stoszek S, Cheret A, Gavart S, Aerssens J, Fuentes R, Rosen B)
Journal:
J Infect Dis.
Publicación independiente
Impact factor
5.226
Q1
Year:
2020
Doi:
PHARMACOKINETICS, SAFETY AND ANTIVIRAL EFFECTS OF MULTIPLE DOSES OF THE RESPIRATORY SYNCYTIAL VIRUS FUSION PROTEIN INHIBITOR, JNJ-53718678, IN INFANTS HOSPITALIZED WITH RSV INFECTION: A RANDOMIZED PHASE 1B STUDY
Federico Martinón-Torres, Sarah Rusch, Dymphy Huntjens, Bart Remmerie, Johan Vingerhoets, Katie McFadyen, Fernando Ferrero, Eugenio Baraldi, Pablo Rojo, Cristina Epalza, Marita Stevens
Journal:
Clin Infect Dis
Publicación independiente
Impact factor
9.079
Q1
Year:
2020
Doi:
https://doi.org/10.1093/cid/ciaa283
DIAGNOSTIC CRITERIA FOR ACUTE FPIES: WHAT ARE WE MISSING?
Marta Vazquez-Ortiz, Laura Argiz, Adrianna Machinena, Luis Echeverria, Cristina Blasco, Ana Prieto, Sonsoles Infante, Leticia Vila, Emilio Garcia, Purificación Gonzalez-Delgado, SoniaVazquez-Cortes, Simona Barni, Frederico Martinon-Torres, BIO-FPIES study network
Journal:
J Allergy Clin Immunol Pract
Publicación independiente
Impact factor
8.861
Q1
Year:
2020
Doi:
https://doi.org/10.1016/j.jaip.2019.11.034
EVALUATION OF THE IMPACT OF THE SPANISH CONSENSUS DOCUMENT ON THE APPROACH TO OSTEOARTICULAR INFECTIONS IN SPAIN THROUGH THE PAEDIATRICS OSTEOARTICULAR INFECTIONS NETWORK (RIOPED).
Nunez Cuadros, Esmeralda; Calvo Rey, Cristina; Saavedra-Lozano, Jesus and Red RIOPED (Federico Martinón and Irene Rivero)
Journal:
An Ped
Publicación independiente
Impact factor
1.500
Q4
Year:
2020
Doi:
IMMUNOGENICITY, TRANSPLACENTAL TRANSFER OF PERTUSSIS ANTIBODIES AND SAFETY FOLLOWING PERTUSSIS IMMUNIZATION DURING PREGNANCY:EVIDENCE FROM A RANDOMIZED, PLACEBO-CONTROLLED TRIAL
Kirsten P. Perrett, Scott A. Halperin, Terry Nolan, Cristina Martínez Pancorbo, Bruce Tapiero, Federico Martinón-Torres, Zbynek Stranak, Miia Virta, Otto G. Vanderkooi, Pavel Kosina, Maria Begoña Encinas Pardilla, Ignacio Cristobal García, Gian Vincenzo Zuccotti, Lusine Kostanyanm, Nadia Meyer, Maria Angeles Ceregido, Brigitte Cheuvart, Sherine O. Kuriyakose, Manuel Marcos Fernández, Miguel Ángel Rodríguez Zambrano, Adrián Martín García, Juan Eloy Asenjo de la Fuente, Maria Dolores Camacho Marín, María de la Calle Fernández-Miranda, Yolanda Romero Espinar, Paola Giovanna Marchisio, Paolo Manzoni, Narcisa Mesaros
Journal:
Vaccine
Publicación independiente
Impact factor
3.641
Q3
Year:
2020
Doi:
https://doi.org/10.1016/j.vaccine.2019.10.105
IMPACT OF TETANUS-DIPHTHERIA-ACELLULAR PERTUSSIS IMMUNIZATION DURING PREGNANCY ON SUBSEQUENT INFANT IMMUNIZATION SERORESPONSES: FOLLOW-UP FROM A LARGE RANDOMIZED PLACEBO-CONTROLLED TRIAL
1Kirsten P. Perrett, Scott A. Halperin, Terry Nolan, Alfonso Carmona Martínez, Federico Martinón-Torres, Jose García-Sicilia, Miia Virta , Otto G. Vanderkooi, Gian Vincenzo Zuccotti, Paolo Manzoni, Lusine Kostanyan, Nadia Meyer, Maria Angeles Ceregido, Brigitte Cheuvart , Sherine O. Kuriyakose l, Zbynek Stranak, Jose M. Merino Arribas, María José Cilleruelo Ortega, Mariano Miranda-Valdivieso, Begoña Arias Novas, Jose Tomas Ramos Amador, Felix Omeñaca, Manuel Baca, Paola Giovanna Marchisio, Narcisa Mesaros
Journal:
Vaccine
Publicación independiente
Impact factor
3.641
Q3
Year:
2020
Doi:
https://doi.org/10.1016/j.vaccine.2019.10.104
SURVEY BY TEDDY EUROPEAN NETWORK OF EXCELLENCE FOR PAEDIATRIC CLINICAL RESEARCH DEMONSTRATES POTENTIAL FOR EUROPE-WIDE TRIALS
Ruggieri L, Bonifazi D, Landi A, Bonifazi F, Bartoloni F, Costello M, Felisi MG, Gasthuys E, Godo A, Martinon Torres F, Nadal D, Nuytinck L, Rocchi F, Turner M, Ceci A
Journal:
Acta paed
Publicación independiente
Impact factor
2.299
Q2
Year:
2020
Doi:
https://doi.org/10.1111/apa.15020
REACTIONS ON RE-EXPOSURE FOLLOWING NEGATIVE AND INCONCLUSIVE FOLLOW-UP FOOD CHALLENGES IN CHILDREN WITH ACUTE FPIES
Laura Argiz, Sonsoles Infante, Adrianna Machinena, Mariona Pascal, Luis Echeverria, Simona Barni, Teresa Garriga-Baraut, Stefania Arasi, Jose Domingo Moure, Alberto Gomez-Carballa, Federico Martinon-Torres, Robert J Boyle, Marta Vazquez-Ortiz, BIO-FPIES study network
Journal:
J Allergy Clin Immunol Pract
Publicación independiente
Impact factor
8.861
Q1
Year:
2020
Doi:
https://doi.org/10.1016/j.jaip.2020.05.040
ENFERMEDAD MENINGOCÓCICA: ¿PODEMOS PREDECIR LO IMPREDECIBLE?
Federico Martinón-Torresy Antoni Trillac
Journal:
Med Clin
Publicación independiente
Impact factor
1.725
Q3
Year:
2020
Doi:
https://doi.org/10.1016/j.medcli.2019.04.035
ROUTINE INFANT VACCINATION OF PNEUMOCOCCAL CONJUGATE VACCINES HAS DECREASED PNEUMONIA ACROSS ALL AGE GROUPS IN NORTHERN SPAIN
I. Rivero-Calle, J. Pardo Seco, P. F. Raguindin, F. Alvez, J. Gómez-Rial, A. Salas, J. Martinón Sanchez and F. Martinón-Torres
Journal:
Hum Vaccine Immunother
Publicación independiente
Impact factor
3.452
Q2
Year:
2020
Doi:
https://doi.org/10.1080/21645515.2019.1690884
QUADRIVALENT INFLUENZA VACCINE PREVENTS ILLNESS AND REDUCES HEALTHCARE UTILIZATION ACROSS DIVERSE GEOGRAPHIC REGIONS DURING FIVE INFLUENZA SEASONS. A RANDOMIZED CLINICAL TRIAL
Ghassan Dbaibo, Arshad Amanullah, Carine Claeys, Allen Izu, Varsha K. Jain, Pope Kosalaraksa, Luis Rivera, Jyoti Soni, Emad Yanni, Khalequ Zaman, Beatriz Acosta, Miguel Ariza, Maria L. Arroba Basanta, Ashish Bavdekar, Alfonso Carmona, Luis Cousin, Jasur Danier, Alfonso Diaz, Javier Diez-Domingo, Ener C. Dinleyici, Saul N. Faust, Jose Garcia-Sicilia, Grace D. Gomez-Go, Maria L. A. Gonzales, Mustafa Hacimustafaoglu, Stephen M. Hughes, Teresa Jackowska, Shashi Kant, Marilla Lucero, Josep Mares Bermudez, Federico Martinón-Torres, May Montellano, Roman Prymula, Thanyawee Puthanakit, Renata Ruzkova, Iwona Sadowska-Krawczenko Henryk Szymanski, Angels Ulied, Wayne Woo, Anne Schuind and Bruce L. Innis for the Flu4VEC Study Group
Journal:
Pediatr Infect Dis J
Publicación independiente
Impact factor
Year:
2020
Doi:
https://doi.org/10.1097/INF.0000000000002504
USE OF THE WHO ACCESS, WATCH, AND RESERVE CLASSIFICATION TO DEFINE PATTERNS OF HOSPITAL ANTIBIOTIC USE (AWARE):AN ANALYSIS OF PAEDIATRIC SURVEY DATA FROM 56 COUNTRIES
1Yingfen Hsia, Brian R Lee, Ann Versporten, Yonghong Yang, Julia Bielicki, Charlotte Jackson, Jason Newland, Herman Goossens, Nicola Magrini, Mike Sharland on behalf of the GARPEC and Global-PPS networks (Federico Martinon Torres, Antonio Justicia
Journal:
Publicación independiente
Impact factor
Year:
2019
Doi:
A QPCR EXPRESSION ASSAY OF IFI44L GENE DIFFERENTIATES VIRAL FROM BACTERIAL INFECTIONS IN FEBRILECHILDREN
Alberto Gómez-Carballa, Miriam Cebey-López, Jacobo Pardo-Seco, Ruth Barral-Arca, Irene Rivero-Calle, Sara Pischedda, María José Currás-Tuala1, José Gómez-Rial, Francisco Barros, Federico Martinón-Torres & Antonio Salas
Journal:
Sci Rep
Publicación independiente
Impact factor
Year:
2019
Doi:
https://doi.org/10.1038/s41598-019-48162-9
MENINGOCOCCAL GROUP B VACCINE FOR THE PREVENTION OF INVASIVE MENINGOCOCCAL DISEASE CAUSED BY NEISSERIA MENINGITIDIS SEROGROUP B
Rivero Calle, I; Raguindin PF; Gómez Rial, J; Rodríguez-Tenreiro, C; Martinón-Torres, F.
Journal:
Infection and Drug Resistance
Publicación independiente
Impact factor
2.984
Q1
Year:
2019
Doi:
https://doi.org/10.2147/IDR.S159952
BACTEREMIA IN CHILDHOOD LIFE-THREATENING INFECTIONS IN URBAN GAMBIA: EUCLIDS IN WEST AFRICA
F Secka, J A Herberg, I Sarr, S Darboe, G Sey, M Saidykhan, M Wathuo, M Kaforou, M Antonio, A Roca, S M A Zaman, M Cebey-López, N P Boeddha, S Paulus, D S Kohlfürst, M Emonts, W Zenz, E D Carrol, R de Groot, L Schlapbach, F Martinon-Torres, K Bojang, M Levin, M van der Flier, S T Anderson on behalf of the EUCLIDS Consortium
Journal:
Open Forum Infectious Diseases
Publicación independiente
Impact factor
3.656
Q2
Year:
2019
Doi:
https://doi.org/10.1093/ofid/ofz332
BIOGEOGRAPHICAL INFORMATIVENESS OF Y-STR HAPLOTYPES
Pardo-Seco, J; Gomez-Carballa, A; Bello, X ; Martinon-Torres, F; Salas, A
Journal:
Science Bulletin
Publicación independiente
Impact factor
9.511
Q1
Year:
2019
Doi:
https://doi.org/10.1016/j.scib.2019.07.025
No results found.
DETECTABLE A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS-1 IN SERUM IS ASSOCIATED WITH ADVERSE OUTCOME IN PEDIATRIC SEPSIS
Boeddha NP, Driessen GJ, Hagedoorn NN, Kohlfuerst DS, Hoggart CJ, van Rijswijk AL, Ekinci E, Priem D, Schlapbach LJ, Herberg JA, de Groot R, Anderson ST, Fink CG, Carrol ED, van der Flier M, Martinón-Torres F, Levin M, Leebeek FW, Zenz W, de Maat MPM, Hazelzet JA, Emonts M, Dik WA.
Doi:
Crit Care Explor
Factor de impacto:
Q1
Doi:
EDITORIAL: VACCINATION OF SPECIAL POPULATIONS: PROTECTING THE VULNERABLE.
O'Connor D, Moschese V, Martinon-Torres F, Palma P.
Doi:
Front Immunol
Factor de impacto:
Q1
Doi:
WORLD HEALTH ORGANIZATION INFLUENZA-LIKE ILLNESS UNDERESTIMATES THE BURDEN OF RESPIRATORY SYNCYTIAL VIRUS INFECTION IN COMMUNITY-DWELLING OLDER ADULTS.
Korsten K, Adriaenssens N, Coenen S, Butler CC, Verheij TJM, Bont LJ, Wildenbeest JG; RESCEU Investigators.(Martinón-Torres F)
Doi:
J Infect Dis
Factor de impacto:
Q1
Doi:
TIPICO XI: REPORT OF THE FIRST SERIES AND PODCAST ON INFECTIOUS DISEASES AND VACCINES (ATIPICO)
Martinón-Torres F, García-Sastre A, Pollard AJ, Martín C, Osterhaus A, Ladhani SN, Ramilo O, Gómez Rial J, Salas A, Bosch FX, Martinón-Torres M, Mina MJ, Cherry J
Doi:
Hum Vaccin Immunother
Factor de impacto:
Q2
Doi:
SUPPORTING NATIONAL IMMUNIZATION TECHNICAL ADVISORY GROUPS IN THE WHO EUROPEAN REGION IN DEVELOPING NATIONAL COVID-19 VACCINATION RECOMMENDATIONS THROUGH ONLINE COMMUNICATION PLATFORM
Mosina L, Külper-Schiek W, Jacques-Carroll L, Earnshaw A, Harder T, Martinón-Torres F, Wilder-Smith A, Wichmann O, Datta SS
Doi:
Vaccine
Factor de impacto:
Q3
Doi:
EXPLORATORY ANALYSIS OF THE ECONOMICALLY JUSTIFIABLE PRICE OF A HYPOTHETICAL RSV VACCINE FOR OLDER ADULTS IN THE NETHERLANDS AND THE UNITED KINGDOM
Zeevat F, Luttjeboer J, Paulissen JHJ, van der Schans J, Beutels P, Boersma C, Postma MJ; RESCEU Investigators. (Martinón-Torres F)
Doi:
J Infect Dis
Factor de impacto:
Q1
Doi:
A SYSTEMATIC REVIEW AND META-ANALYSIS OF ANIMAL STUDIES INVESTIGATING THE RELATIONSHIP BETWEEN SERUM ANTIBODY, T LYMPHOCYTES, AND RESPIRATORY SYNCYTIAL VIRUS DISEASE
McGinley J, Thwaites R, Brebner W, Greenan-Barrett L, Aerssens J, Öner D, Bont L, Wildenbeest J, Martinón-Torres F, Nair H, Pollard AJ, Openshaw P, Drysdale S; REspiratory Syncytial virus Consortium in EUrope (RESCEU) Investigators
Doi:
J Infect Dis
Factor de impacto:
Q1
Doi:
PUBLISHER CORRECTION: DISTINCT PATTERNS OF WITHIN-HOST VIRUS POPULATIONS BETWEEN TWO SUBGROUPS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS
Lin GL, Drysdale SB, Snape MD, O'Connor D, Brown A, MacIntyre-Cockett G, Mellado-Gomez E, de Cesare M, Bonsall D, Ansari MA, Öner D, Aerssens J, Butler C, Bont L, Openshaw P, Martinón-Torres F, Nair H, Bowden R; RESCEU Investigators, Golubchik T, Pollard AJ
Doi:
Nat Commun
Factor de impacto:
Q1
Doi:
DISEASE BURDEN ESTIMATES OF RESPIRATORY SYNCYTIAL VIRUS RELATED ACUTE RESPIRATORY INFECTIONS IN ADULTS WITH COMORBIDITY: A SYSTEMATIC REVIEW AND META-ANALYSIS
Shi T, Vennard S, Jasiewicz F, Brogden R, Nair H; RESCEU Investigators. (Martinón-Torres F)
Doi:
J Infect Dis
Factor de impacto:
Q1
Doi:
SUPERSPREADING IN THE EMERGENCE OF COVID-19 VARIANTS
Gómez-Carballa A, Pardo-Seco J, Bello X, Martinón-Torres F, Salas A
Doi:
Trends Genet
Factor de impacto:
Q1
Doi:
ROUTINE INFANT VACCINATION OF PNEUMOCOCCAL CONJUGATE VACCINES HAS DECREASED PNEUMONIA ACROSS ALL AGE GROUPS IN NORTHERN SPAIN
I. Rivero-Calle, J. Pardo Seco, P. F. Raguindin, F. Alvez, J. Gómez-Rial, A. Salas, J. Martinón Sanchez and F. Martinón-Torres
Hum Vaccine Immunother
Factor de impacto:
Q2
Doi:
QUADRIVALENT INFLUENZA VACCINE PREVENTS ILLNESS AND REDUCES HEALTHCARE UTILIZATION ACROSS DIVERSE GEOGRAPHIC REGIONS DURING FIVE INFLUENZA SEASONS. A RANDOMIZED CLINICAL TRIAL
Ghassan Dbaibo, Arshad Amanullah, Carine Claeys, Allen Izu, Varsha K. Jain, Pope Kosalaraksa, Luis Rivera, Jyoti Soni, Emad Yanni, Khalequ Zaman, Beatriz Acosta, Miguel Ariza, Maria L. Arroba Basanta, Ashish Bavdekar, Alfonso Carmona, Luis Cousin, Jasur Danier, Alfonso Diaz, Javier Diez-Domingo, Ener C. Dinleyici, Saul N. Faust, Jose Garcia-Sicilia, Grace D. Gomez-Go, Maria L. A. Gonzales, Mustafa Hacimustafaoglu, Stephen M. Hughes, Teresa Jackowska, Shashi Kant, Marilla Lucero, Josep Mares Bermudez, Federico Martinón-Torres, May Montellano, Roman Prymula, Thanyawee Puthanakit, Renata Ruzkova, Iwona Sadowska-Krawczenko Henryk Szymanski, Angels Ulied, Wayne Woo, Anne Schuind and Bruce L. Innis for the Flu4VEC Study Group
Pediatr Infect Dis J
Factor de impacto:
Doi:
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