Our main research line is meningococcal disease, covering the topic from basic research focused on the host genetic background, to therapeutics and vaccines assessment through randomized controlled clinical trials. This research activity has been mainly developed in association with other centres, first through ESIGEM (Spanish national network on MD research www.esigem.org) and now as part of the EUCLIDS consortium (www.euclids-project.eu).
This approach is now being applied to other severe and life-threatening bacterial infections, namely, pneumococcal, streptococcal, staphylococcal and salmonella diseases.
The assessment of the clinical phenotype and course of viral respiratory infections in pediatric patients, with special attention to the role of D vitamin, the host genetics and transcriptomics, constitutes one of our more active research lines (www.gendres.org).
Acute bronchiolitis and the assessment of new therapeutic options for this entity like heliox therapy has finally led us to the development of clinical guidelines for the therapeutic management of bronchiolitis and also for the use of the helium-oxygen mixtures in this and other settings.
We study how the genetic code explains the ancestry structure among different populations. We have extensive experience and results in this approach.
Mitochondrial DNA, due to its peculiarities, is a useful tool in the area of population genetics. In GENVIP we have one of the first line researchers in the field, Antonio Salas, with more than 60 scientific publications concerning many aspects of mitochondrial DNA. We are specifically exploring this approach in the setting of pediatric infectious diseases.